Tearing the Envelope: Harriet Jacobs’s “Epistolary Activism”

Epistolary Justice: The Love Letter as Law

Nuclear Envelope Breakdown Proceeds by Microtubule-Induced Tearing of the Lamina

The mechanism of nuclear envelope breakdown (NEBD) was investigated in live cells. Early spindle microtubules caused folds and invaginations in the NE up to one hour prior to NEBD, creating mechanical tension in the nuclear lamina. The first gap in the NE appeared before lamin B depolymerization, at the site of maximal tension, by a tearing mechanism. Gap formation relaxed this tension and dram...

Epistolary Consultations on Venereal Disease 69 Epistolary Consultations on Venereal Disease in Eighteenth-Century France

This essay examines the way in which medical consultations by letter were employed to seek and receive advice on venereal diseases in eighteenth-century France. Epistolary consultations from across eighteenth-century Europe have been used by historians for purposes that have included examining physician/patient power relationships; as a reflection of medical practice; to analyze perceptions of ...

Tearing down the spindle

isassembly of the mitotic spindle takes some effort, according to Kan Cao, Yixian Zheng (Johns Hopkins University, Baltimore, MD), and colleagues, who show that an ATPase and its binding partners pull apart the spindle. The spindle is put together by assembly factors that are activated by the cyclin-dependent kinase Cdc2. The loss of Cdc2 activity at the end of mitosis has thus been the convent...

Tearing down the Internet

Recent advances in scale-free networks have claimed that their topologies are very weak against attacks. The inhomogeneous connectivity distribution of large-scale current communication networks, such as the Internet, could be exploited by evil hackers in order to damage these systems. However, there have not been many studies on the approaches and consequences of such targeted attacks. In this...